Drug interactions
Butorphanol + Trimipramine
Severity: Moderate
Butorphanol and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a strongly sedating tricyclic antidepressant, and combining it with butorphanol can cause excessive sedation, respiratory depression and hypotension. Anticholinergic effects such as constipation and urinary retention may also be worsened.
What this interaction means in plain words
Butorphanol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid activity and the antihistaminic and anticholinergic properties of the tricyclic.
What to do
Begin with reduced doses and monitor sedation, breathing and anticholinergic effects. Avoid or reduce the dose further in older or respiratory-compromised patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Butorphanol with Trimipramine?
MediHelp rates the interaction as moderate. Butorphanol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a strongly sedating tricyclic antidepressant, and combining it with butorphanol can cause excessive sedation, respiratory depression and hypotension. Anticholinergic effects such as constipation and urinary retention may also be worsened.
How serious is the interaction between Butorphanol and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin with reduced doses and monitor sedation, breathing and anticholinergic effects. Avoid or reduce the dose further in older or respiratory-compromised patients.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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