Drug interactions
Cabazitaxel + Cimetidine
Severity: Moderate
Cabazitaxel and Cimetidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase cabazitaxel exposure, with potential for greater neutropenia and gastrointestinal toxicity. Cabazitaxel is a CYP3A4 substrate with a narrow therapeutic window.
What this interaction means in plain words
Cabazitaxel and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine inhibits CYP3A4, reducing cabazitaxel clearance.
What to do
Monitor neutrophil counts closely and consider famotidine or another non-inhibiting acid suppressant. Reduce cabazitaxel dose if severe toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Cimetidine?
MediHelp rates the interaction as moderate. Cabazitaxel and Cimetidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine may increase cabazitaxel exposure, with potential for greater neutropenia and gastrointestinal toxicity. Cabazitaxel is a CYP3A4 substrate with a narrow therapeutic window.
How serious is the interaction between Cabazitaxel and Cimetidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts closely and consider famotidine or another non-inhibiting acid suppressant. Reduce cabazitaxel dose if severe toxicity develops.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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