Drug interactions
Cabazitaxel + Duvelisib
Severity: Moderate
Cabazitaxel and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a moderate CYP3A4 inhibitor and may increase cabazitaxel concentrations. Higher exposure can worsen myelosuppression and other adverse effects.
What this interaction means in plain words
Cabazitaxel and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, reducing cabazitaxel metabolism.
What to do
Monitor complete blood counts frequently and consider reducing the cabazitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Cabazitaxel with Duvelisib?
MediHelp rates the interaction as moderate. Cabazitaxel and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a moderate CYP3A4 inhibitor and may increase cabazitaxel concentrations. Higher exposure can worsen myelosuppression and other adverse effects.
How serious is the interaction between Cabazitaxel and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and consider reducing the cabazitaxel dose if toxicity develops.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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