Drug interactions
Cabazitaxel + Lapatinib
Severity: Moderate
Cabazitaxel and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib weakly to moderately inhibits CYP3A4 and P-glycoprotein and may raise cabazitaxel levels. This could increase neutropenia and diarrhea.
What this interaction means in plain words
Cabazitaxel and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4 and P-glycoprotein, decreasing cabazitaxel clearance.
What to do
Monitor neutrophil counts and gastrointestinal toxicity, with cabazitaxel dose reduction if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Cabazitaxel with Lapatinib?
MediHelp rates the interaction as moderate. Cabazitaxel and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib weakly to moderately inhibits CYP3A4 and P-glycoprotein and may raise cabazitaxel levels. This could increase neutropenia and diarrhea.
How serious is the interaction between Cabazitaxel and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and gastrointestinal toxicity, with cabazitaxel dose reduction if toxicity occurs.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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