Drug interactions
Cabazitaxel + Nicardipine
Severity: Moderate
Cabazitaxel and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine can inhibit CYP3A4 and may increase cabazitaxel exposure. This raises the risk of neutropenia, diarrhea and other serious cabazitaxel toxicity.
What this interaction means in plain words
Cabazitaxel and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 reduces cabazitaxel metabolic clearance; nicardipine is only a weak to moderate inhibitor.
What to do
Monitor neutrophil counts and gastrointestinal toxicity closely and consider an alternative antihypertensive such as a non-CYP3A4-inhibiting agent. Reduce the cabazitaxel dose if severe toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Nicardipine?
MediHelp rates the interaction as moderate. Cabazitaxel and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine can inhibit CYP3A4 and may increase cabazitaxel exposure. This raises the risk of neutropenia, diarrhea and other serious cabazitaxel toxicity.
How serious is the interaction between Cabazitaxel and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and gastrointestinal toxicity closely and consider an alternative antihypertensive such as a non-CYP3A4-inhibiting agent. Reduce the cabazitaxel dose if severe toxicity occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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