Drug interactions
Cabazitaxel + Verapamil
Severity: Moderate
Cabazitaxel and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise cabazitaxel concentrations and increase the risk of neutropenia and other toxicities. Cabazitaxel is mainly cleared by CYP3A4.
What this interaction means in plain words
Cabazitaxel and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, and possibly P-glycoprotein, reducing cabazitaxel clearance.
What to do
Monitor blood counts closely and reduce the cabazitaxel dose if severe neutropenia occurs. Consider an alternative to verapamil if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Verapamil?
MediHelp rates the interaction as moderate. Cabazitaxel and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise cabazitaxel concentrations and increase the risk of neutropenia and other toxicities. Cabazitaxel is mainly cleared by CYP3A4.
How serious is the interaction between Cabazitaxel and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and reduce the cabazitaxel dose if severe neutropenia occurs. Consider an alternative to verapamil if possible.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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