Drug interactions
Cabotegravir + Calcium carbonate
Severity: Moderate
Cabotegravir and Calcium carbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium-containing antacids may bind oral cabotegravir in the gut and reduce its absorption. Lower exposure could weaken virologic control.
What this interaction means in plain words
Cabotegravir and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabotegravir belongs to Anti Virals; Calcium carbonate belongs to Gastrointestinal Tract.
Why it happens
Calcium cations chelate cabotegravir in the gastrointestinal tract, decreasing absorption.
What to do
Give oral cabotegravir at least 2 hours before or 4 hours after calcium carbonate antacids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Calcium carbonate?
MediHelp rates the interaction as moderate. Cabotegravir and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium-containing antacids may bind oral cabotegravir in the gut and reduce its absorption. Lower exposure could weaken virologic control.
How serious is the interaction between Cabotegravir and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral cabotegravir at least 2 hours before or 4 hours after calcium carbonate antacids.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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