Drug interactions
Cabotegravir + Magnesium hydroxide
Severity: Moderate
Cabotegravir and Magnesium hydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium antacids chelate oral cabotegravir in the gut and may lower its plasma levels, risking reduced antiviral effect. This applies to the oral formulation only.
What this interaction means in plain words
Cabotegravir and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabotegravir belongs to Anti Virals; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Magnesium cations chelate cabotegravir in the GI tract, reducing absorption.
What to do
Give the antacid at least 2 hours before or 4 hours after oral cabotegravir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Cabotegravir and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium antacids chelate oral cabotegravir in the gut and may lower its plasma levels, risking reduced antiviral effect. This applies to the oral formulation only.
How serious is the interaction between Cabotegravir and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the antacid at least 2 hours before or 4 hours after oral cabotegravir.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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