Drug interactions
Cabozantinib + Nevirapine
Severity: Major
Cabozantinib and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine can reduce cabozantinib concentrations and may lower anticancer efficacy.
What this interaction means in plain words
Cabozantinib and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabozantinib belongs to Oncology; Nevirapine belongs to Anti Virals.
Why it happens
CYP3A4 induction by nevirapine accelerates cabozantinib metabolism.
What to do
Avoid the combination if possible. If unavoidable, increase the cabozantinib dose per labeling and return to the usual dose a few days after nevirapine is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Nevirapine?
MediHelp rates the interaction as major. Cabozantinib and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine can reduce cabozantinib concentrations and may lower anticancer efficacy.
How serious is the interaction between Cabozantinib and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If unavoidable, increase the cabozantinib dose per labeling and return to the usual dose a few days after nevirapine is stopped.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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