Drug interactions
Caffeine + Calcium
Severity: Minor
Caffeine and Calcium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine causes a small increase in urinary calcium excretion, which is generally offset by a modest dietary calcium intake. It is only relevant with very high caffeine consumption and low calcium intake.
What this interaction means in plain words
Caffeine and Calcium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Calcium belongs to Gastrointestinal Tract.
Why it happens
Caffeine mildly increases renal calcium excretion and may slightly reduce absorption.
What to do
No action needed for most patients. Ensure adequate calcium intake in those with osteoporosis who consume large amounts of caffeine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Calcium?
MediHelp rates the interaction as minor. Caffeine and Calcium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine causes a small increase in urinary calcium excretion, which is generally offset by a modest dietary calcium intake. It is only relevant with very high caffeine consumption and low calcium intake.
How serious is the interaction between Caffeine and Calcium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed for most patients. Ensure adequate calcium intake in those with osteoporosis who consume large amounts of caffeine.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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