Drug interactions
Caffeine + Oxymorphone
Severity: Minor
Caffeine and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine is a mild stimulant and may partly counteract opioid drowsiness, though it does not prevent respiratory depression. Caffeine can also modestly enhance analgesia. No clinically important interaction is expected.
What this interaction means in plain words
Caffeine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Oxymorphone belongs to Musculoskeletal.
Why it happens
Opposing pharmacodynamic effects on arousal through adenosine receptor antagonism by caffeine.
What to do
No action is generally required. Do not assume caffeine reduces the risk of opioid overdose and monitor sedation as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Caffeine and Oxymorphone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Oxymorphone?
MediHelp rates the interaction as minor. Caffeine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine is a mild stimulant and may partly counteract opioid drowsiness, though it does not prevent respiratory depression. Caffeine can also modestly enhance analgesia. No clinically important interaction is expected.
How serious is the interaction between Caffeine and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required. Do not assume caffeine reduces the risk of opioid overdose and monitor sedation as usual.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
