Drug interactions
Caffeine + Verapamil
Severity: Minor
Caffeine and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP1A2 to a modest degree and can reduce caffeine clearance, prolonging its stimulant effects. Effects such as jitteriness, palpitations or insomnia may be more noticeable with high caffeine intake.
What this interaction means in plain words
Caffeine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP1A2-mediated caffeine metabolism by verapamil.
What to do
Advise patients to moderate caffeine intake if they experience tremor, palpitations or sleep disturbance. No dose change is normally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Verapamil?
MediHelp rates the interaction as minor. Caffeine and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits CYP1A2 to a modest degree and can reduce caffeine clearance, prolonging its stimulant effects. Effects such as jitteriness, palpitations or insomnia may be more noticeable with high caffeine intake.
How serious is the interaction between Caffeine and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to moderate caffeine intake if they experience tremor, palpitations or sleep disturbance. No dose change is normally needed.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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