Drug interactions
Calcitriol + Larotrectinib
Severity: Minor
Calcitriol and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and a weak inhibitor in vitro, and calcitriol is partly metabolized by CYP3A4, so a small rise in calcitriol exposure is conceivable. No clinically significant effect has been established.
What this interaction means in plain words
Calcitriol and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcitriol belongs to Musculoskeletal; Larotrectinib belongs to Oncology.
Why it happens
Theoretical weak CYP3A4 inhibition by larotrectinib reducing calcitriol clearance.
What to do
No dose adjustment is needed; monitor serum calcium as part of routine calcitriol therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcitriol
- Amlodipine-hydrochlorothiazide-valsartan + Calcitriol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcitriol Moderate
- Amobarbital + Calcitriol Moderate
- Apalutamide + Calcitriol Moderate
- Atazanavir + Calcitriol Moderate
- Atenolol-chlorthalidone + Calcitriol Moderate
Other interactions of Larotrectinib
Frequently asked questions
Can I take Calcitriol with Larotrectinib?
MediHelp rates the interaction as minor. Calcitriol and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and a weak inhibitor in vitro, and calcitriol is partly metabolized by CYP3A4, so a small rise in calcitriol exposure is conceivable. No clinically significant effect has been established.
How serious is the interaction between Calcitriol and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor serum calcium as part of routine calcitriol therapy.
What other medicines interact with Calcitriol?
MediHelp also lists interactions of Calcitriol with, for example, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide, Amobarbital. The full list is on the Calcitriol page.
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