Drug interactions
Calcium acetate + Eltrombopag
Severity: Moderate
Calcium acetate and Eltrombopag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium acetate can bind eltrombopag in the gut and markedly reduce its absorption. This may lead to subtherapeutic platelet responses.
What this interaction means in plain words
Calcium acetate and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Eltrombopag belongs to Miscellaneous.
Why it happens
Polyvalent cations chelate eltrombopag in the gastrointestinal tract, reducing absorption.
What to do
Give eltrombopag at least 2 hours before or 4 hours after calcium-containing products. Monitor platelet counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Eltrombopag?
MediHelp rates the interaction as moderate. Calcium acetate and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium acetate can bind eltrombopag in the gut and markedly reduce its absorption. This may lead to subtherapeutic platelet responses.
How serious is the interaction between Calcium acetate and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give eltrombopag at least 2 hours before or 4 hours after calcium-containing products. Monitor platelet counts.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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