Drug interactions
Calcium acetate + Enalapril-hydrochlorothiazide
Severity: Moderate
Calcium acetate and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, so taking calcium salts with hydrochlorothiazide can raise serum calcium. With large calcium doses, hypercalcemia and milk-alkali type problems can occur.
What this interaction means in plain words
Calcium acetate and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides increase distal tubular calcium reabsorption, which adds to calcium intake.
What to do
Monitor serum calcium periodically, especially with high calcium doses or renal impairment, and reduce the calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcium acetate and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, so taking calcium salts with hydrochlorothiazide can raise serum calcium. With large calcium doses, hypercalcemia and milk-alkali type problems can occur.
How serious is the interaction between Calcium acetate and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially with high calcium doses or renal impairment, and reduce the calcium dose if hypercalcemia develops.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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