Drug interactions
Calcium acetate + Hydrochlorothiazide-losartan
Severity: Moderate
Calcium acetate and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, so calcium supplements or binders can lead to hypercalcemia, particularly in renal impairment or with high doses. Rarely the milk-alkali syndrome with alkalosis may occur.
What this interaction means in plain words
Calcium acetate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Thiazide-induced increase in renal tubular calcium reabsorption adds to calcium intake.
What to do
Monitor serum calcium periodically, especially with high calcium doses or kidney disease. Reduce the calcium dose if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Calcium acetate and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, so calcium supplements or binders can lead to hypercalcemia, particularly in renal impairment or with high doses. Rarely the milk-alkali syndrome with alkalosis may occur.
How serious is the interaction between Calcium acetate and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially with high calcium doses or kidney disease. Reduce the calcium dose if hypercalcemia occurs.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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