Drug interactions
Calcium acetate + Levofloxacin
Severity: Moderate
Calcium acetate and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium binds levofloxacin in the gut and can reduce its absorption, which may lower antibiotic levels and risk treatment failure. The effect applies to oral dosing of both agents.
What this interaction means in plain words
Calcium acetate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Levofloxacin belongs to Anti Bacterial.
Why it happens
Chelation of levofloxacin by divalent calcium cations in the gastrointestinal tract, reducing absorption.
What to do
Give oral levofloxacin at least 2 hours before or after calcium acetate. Phosphate binder timing should be arranged around meals accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Levofloxacin?
MediHelp rates the interaction as moderate. Calcium acetate and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium binds levofloxacin in the gut and can reduce its absorption, which may lower antibiotic levels and risk treatment failure. The effect applies to oral dosing of both agents.
How serious is the interaction between Calcium acetate and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral levofloxacin at least 2 hours before or after calcium acetate. Phosphate binder timing should be arranged around meals accordingly.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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