Drug interactions
Calcium + Diflunisal
Severity: Minor
Calcium and Diflunisal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate can alkalinize urine and so alter renal excretion of salicylates such as diflunisal. Effects on drug levels are small and variable and rarely clinically important.
What this interaction means in plain words
Calcium and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Diflunisal belongs to Musculoskeletal.
Why it happens
Alkaline urine increases ionization of salicylic acid derivatives, reducing tubular reabsorption and raising excretion.
What to do
No specific action is needed. Monitor analgesic response or salicylate effects if large antacid doses are used chronically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Calcium with Diflunisal?
MediHelp rates the interaction as minor. Calcium and Diflunisal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium carbonate can alkalinize urine and so alter renal excretion of salicylates such as diflunisal. Effects on drug levels are small and variable and rarely clinically important.
How serious is the interaction between Calcium and Diflunisal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed. Monitor analgesic response or salicylate effects if large antacid doses are used chronically.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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