Drug interactions
Calcium + Mesalamine
Severity: Minor
Calcium and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate may alkalinize urine and alter salicylate excretion. Mesalamine acts mainly locally in the colon with limited systemic absorption, so the effect is minimal. Antacids may also affect pH-dependent release of some mesalamine formulations.
What this interaction means in plain words
Calcium and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Urinary alkalinization raises salicylate excretion, and higher gastric pH may alter pH-dependent mesalamine release.
What to do
No routine action is needed. Separate antacids from pH-dependent mesalamine formulations if disease control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Mesalamine
Frequently asked questions
Can I take Calcium with Mesalamine?
MediHelp rates the interaction as minor. Calcium and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium carbonate may alkalinize urine and alter salicylate excretion. Mesalamine acts mainly locally in the colon with limited systemic absorption, so the effect is minimal. Antacids may also affect pH-dependent release of some mesalamine formulations.
How serious is the interaction between Calcium and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Separate antacids from pH-dependent mesalamine formulations if disease control worsens.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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