Drug interactions
Calcium + Neratinib
Severity: Moderate
Calcium and Neratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neratinib absorption depends on acidic gastric conditions, and calcium carbonate antacids raise gastric pH. Reduced exposure may lessen anticancer efficacy.
What this interaction means in plain words
Calcium and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Neratinib belongs to Oncology.
Why it happens
Higher gastric pH decreases the solubility and absorption of neratinib.
What to do
Take neratinib at least 3 hours after antacids. Avoid acid-reducing agents that cannot be separated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Neratinib
- Amiodarone + Neratinib Major
- Amobarbital + Neratinib Major
- Aprepitant + Neratinib Major
- Armodafinil + Neratinib Major
- Bosentan + Neratinib Major
- Carbamazepine + Neratinib Major
Frequently asked questions
Can I take Calcium with Neratinib?
MediHelp rates the interaction as moderate. Calcium and Neratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neratinib absorption depends on acidic gastric conditions, and calcium carbonate antacids raise gastric pH. Reduced exposure may lessen anticancer efficacy.
How serious is the interaction between Calcium and Neratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take neratinib at least 3 hours after antacids. Avoid acid-reducing agents that cannot be separated.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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