Drug interactions
Calcium + Pexidartinib
Severity: Moderate
Calcium and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing calcium carbonate may lower pexidartinib absorption through increased gastric pH. Reduced exposure could decrease efficacy.
What this interaction means in plain words
Calcium and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Pexidartinib belongs to Oncology.
Why it happens
Elevated gastric pH reduces pexidartinib solubility and absorption.
What to do
Take pexidartinib at least 2 hours before or after locally acting antacids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Pexidartinib
Frequently asked questions
Can I take Calcium with Pexidartinib?
MediHelp rates the interaction as moderate. Calcium and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing calcium carbonate may lower pexidartinib absorption through increased gastric pH. Reduced exposure could decrease efficacy.
How serious is the interaction between Calcium and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take pexidartinib at least 2 hours before or after locally acting antacids.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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