Drug interactions
Calcium + Riociguat
Severity: Moderate
Calcium and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids containing calcium carbonate can lower oral riociguat exposure. Reduced exposure may weaken the pulmonary vasodilator effect.
What this interaction means in plain words
Calcium and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Riociguat belongs to Cardiovascular.
Why it happens
Higher gastric pH and possible binding reduce riociguat absorption.
What to do
Take riociguat at least 1 hour before or after the antacid. Monitor symptoms and exercise tolerance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Calcium with Riociguat?
MediHelp rates the interaction as moderate. Calcium and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids containing calcium carbonate can lower oral riociguat exposure. Reduced exposure may weaken the pulmonary vasodilator effect.
How serious is the interaction between Calcium and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take riociguat at least 1 hour before or after the antacid. Monitor symptoms and exercise tolerance.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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