Drug interactions
Calcium carbonate + Eprosartan-hydrochlorothiazide
Severity: Moderate
Calcium carbonate and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides lower urinary calcium excretion, so calcium supplements can lead to hypercalcemia and, with large doses, milk-alkali syndrome with metabolic alkalosis. The risk is highest with high calcium intake or renal impairment.
What this interaction means in plain words
Calcium carbonate and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Eprosartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazide-enhanced renal calcium reabsorption combined with added calcium and alkali load.
What to do
Monitor serum calcium and avoid high-dose calcium carbonate with the thiazide; reduce the calcium dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcium carbonate and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides lower urinary calcium excretion, so calcium supplements can lead to hypercalcemia and, with large doses, milk-alkali syndrome with metabolic alkalosis. The risk is highest with high calcium intake or renal impairment.
How serious is the interaction between Calcium carbonate and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and avoid high-dose calcium carbonate with the thiazide; reduce the calcium dose if levels rise.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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