Drug interactions
Calcium carbonate + Erdafitinib
Severity: Moderate
Calcium carbonate and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib dose titration is guided by serum phosphate rise, which is a pharmacodynamic effect of FGFR inhibition. Calcium carbonate is used as a phosphate binder and may lower phosphate, obscuring dose-escalation decisions.
What this interaction means in plain words
Calcium carbonate and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Erdafitinib belongs to Oncology.
Why it happens
Phosphate binding by calcium carbonate lowers serum phosphate, confounding the pharmacodynamic marker used to guide erdafitinib dosing.
What to do
Avoid phosphate binders including calcium carbonate during the first 21 days of erdafitinib while the dose is being titrated. Monitor serum phosphate if a binder is later required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium carbonate and Erdafitinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Calcium carbonate
Other interactions of Erdafitinib
Frequently asked questions
Can I take Calcium carbonate with Erdafitinib?
MediHelp rates the interaction as moderate. Calcium carbonate and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib dose titration is guided by serum phosphate rise, which is a pharmacodynamic effect of FGFR inhibition. Calcium carbonate is used as a phosphate binder and may lower phosphate, obscuring dose-escalation decisions.
How serious is the interaction between Calcium carbonate and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid phosphate binders including calcium carbonate during the first 21 days of erdafitinib while the dose is being titrated. Monitor serum phosphate if a binder is later required.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
