Drug interactions
Calcium carbonate + Hydrochlorothiazide-telmisartan
Severity: Moderate
Calcium carbonate and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides decrease urinary calcium excretion, and with calcium supplements this can lead to hypercalcemia, and with large doses of carbonate, metabolic alkalosis (milk-alkali syndrome). The risk is mainly with high doses or renal impairment.
What this interaction means in plain words
Calcium carbonate and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Reduced renal calcium excretion by thiazides adds to calcium load from supplements, with alkali contributing to alkalosis.
What to do
Monitor serum calcium in patients on high-dose calcium or with renal impairment, and reduce the calcium dose if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Calcium carbonate and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides decrease urinary calcium excretion, and with calcium supplements this can lead to hypercalcemia, and with large doses of carbonate, metabolic alkalosis (milk-alkali syndrome). The risk is mainly with high doses or renal impairment.
How serious is the interaction between Calcium carbonate and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium in patients on high-dose calcium or with renal impairment, and reduce the calcium dose if hypercalcemia occurs.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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