Drug interactions
Calcium carbonate + Hydrochlorothiazide-valsartan
Severity: Moderate
Calcium carbonate and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides decrease urinary calcium excretion, so supplemental calcium can lead to hypercalcemia. Calcium carbonate with absorbable alkali can also contribute to metabolic alkalosis, mostly with large doses or renal impairment.
What this interaction means in plain words
Calcium carbonate and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Reduced renal calcium clearance by thiazides combined with calcium load and alkali intake.
What to do
Monitor serum calcium in patients taking regular calcium supplements or high-dose antacids. Reduce the calcium dose if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Calcium carbonate and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides decrease urinary calcium excretion, so supplemental calcium can lead to hypercalcemia. Calcium carbonate with absorbable alkali can also contribute to metabolic alkalosis, mostly with large doses or renal impairment.
How serious is the interaction between Calcium carbonate and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium in patients taking regular calcium supplements or high-dose antacids. Reduce the calcium dose if hypercalcemia occurs.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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