Drug interactions
Calcium carbonate + Ketoconazole
Severity: Moderate
Calcium carbonate and Ketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole requires gastric acid to dissolve, so antacids can markedly reduce its absorption and may result in antifungal treatment failure.
What this interaction means in plain words
Calcium carbonate and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Ketoconazole belongs to Anti Fungals.
Why it happens
Increased gastric pH reduces dissolution and absorption of ketoconazole.
What to do
Give calcium carbonate at least 2 hours after ketoconazole. Monitor antifungal response with regular antacid use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Ketoconazole?
MediHelp rates the interaction as moderate. Calcium carbonate and Ketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole requires gastric acid to dissolve, so antacids can markedly reduce its absorption and may result in antifungal treatment failure.
How serious is the interaction between Calcium carbonate and Ketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give calcium carbonate at least 2 hours after ketoconazole. Monitor antifungal response with regular antacid use.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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