Drug interactions
Calcium carbonate + Ledipasvir-sofosbuvir
Severity: Moderate
Calcium carbonate and Ledipasvir-sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate neutralizes gastric acid, and ledipasvir is less soluble at higher pH. Absorption of ledipasvir may fall, possibly reducing antiviral efficacy.
What this interaction means in plain words
Calcium carbonate and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
Elevated gastric pH reduces ledipasvir solubility and absorption.
What to do
Give calcium carbonate at least 4 hours apart from ledipasvir/sofosbuvir.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as moderate. Calcium carbonate and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium carbonate neutralizes gastric acid, and ledipasvir is less soluble at higher pH. Absorption of ledipasvir may fall, possibly reducing antiviral efficacy.
How serious is the interaction between Calcium carbonate and Ledipasvir-sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give calcium carbonate at least 4 hours apart from ledipasvir/sofosbuvir.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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