Drug interactions
Calcium carbonate + Nilotinib
Severity: Moderate
Calcium carbonate and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib solubility falls as gastric pH rises, so antacids may reduce its absorption. Lower exposure could reduce efficacy in leukemia treatment.
What this interaction means in plain words
Calcium carbonate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Nilotinib belongs to Oncology.
Why it happens
Increased gastric pH decreases the pH-dependent solubility and absorption of nilotinib.
What to do
Take the antacid at least 2 hours before or 2 hours after nilotinib. Remember nilotinib must be taken fasting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Calcium carbonate with Nilotinib?
MediHelp rates the interaction as moderate. Calcium carbonate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib solubility falls as gastric pH rises, so antacids may reduce its absorption. Lower exposure could reduce efficacy in leukemia treatment.
How serious is the interaction between Calcium carbonate and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the antacid at least 2 hours before or 2 hours after nilotinib. Remember nilotinib must be taken fasting.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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