Drug interactions
Calcium carbonate + Pazopanib
Severity: Moderate
Calcium carbonate and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption depends on gastric acidity, and drugs raising gastric pH can reduce its exposure. Lower exposure may blunt antitumour efficacy.
What this interaction means in plain words
Calcium carbonate and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Increased gastric pH reduces dissolution of pazopanib, which has pH-dependent solubility.
What to do
If an antacid is required, give pazopanib at least 1 hour before or 2 hours after it. Prefer short-acting antacids over proton pump inhibitors or H2 blockers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Calcium carbonate with Pazopanib?
MediHelp rates the interaction as moderate. Calcium carbonate and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib absorption depends on gastric acidity, and drugs raising gastric pH can reduce its exposure. Lower exposure may blunt antitumour efficacy.
How serious is the interaction between Calcium carbonate and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is required, give pazopanib at least 1 hour before or 2 hours after it. Prefer short-acting antacids over proton pump inhibitors or H2 blockers.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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