Drug interactions
Calcium carbonate + Sofosbuvir-velpatasvir
Severity: Moderate
Calcium carbonate and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate raises gastric pH, and velpatasvir absorption declines as pH rises. Antiviral exposure may drop and reduce efficacy.
What this interaction means in plain words
Calcium carbonate and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Increased gastric pH decreases velpatasvir solubility.
What to do
Separate calcium carbonate from sofosbuvir-velpatasvir by at least 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Calcium carbonate with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Calcium carbonate and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium carbonate raises gastric pH, and velpatasvir absorption declines as pH rises. Antiviral exposure may drop and reduce efficacy.
How serious is the interaction between Calcium carbonate and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate calcium carbonate from sofosbuvir-velpatasvir by at least 4 hours.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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