Drug interactions
Calcium chloride + Hydrochlorothiazide
Severity: Moderate
Calcium chloride and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides reduce urinary calcium excretion, so added calcium can lead to hypercalcaemia. Risk is greatest with repeated or high doses and in renal impairment.
What this interaction means in plain words
Calcium chloride and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides increase distal tubular calcium reabsorption, decreasing renal calcium clearance.
What to do
Monitor serum calcium and renal function, and reduce the calcium dose if hypercalcaemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Calcium chloride with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcium chloride and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazides reduce urinary calcium excretion, so added calcium can lead to hypercalcaemia. Risk is greatest with repeated or high doses and in renal impairment.
How serious is the interaction between Calcium chloride and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function, and reduce the calcium dose if hypercalcaemia develops.
What other medicines interact with Hydrochlorothiazide?
MediHelp also lists interactions of Hydrochlorothiazide with, for example, Dofetilide, Amifostine, Amiodarone. The full list is on the Hydrochlorothiazide page.
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