Drug interactions
Calcium chloride + Metolazone
Severity: Moderate
Calcium chloride and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone lowers urinary calcium excretion, so administered calcium may accumulate and cause hypercalcemia. This matters most with repeated or large doses of calcium or in patients with reduced renal function.
What this interaction means in plain words
Calcium chloride and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Metolazone enhances distal tubular calcium reabsorption, decreasing urinary calcium loss.
What to do
Check serum calcium after repeated calcium chloride dosing and during long-term co-therapy. Adjust the calcium dose according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Calcium chloride with Metolazone?
MediHelp rates the interaction as moderate. Calcium chloride and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone lowers urinary calcium excretion, so administered calcium may accumulate and cause hypercalcemia. This matters most with repeated or large doses of calcium or in patients with reduced renal function.
How serious is the interaction between Calcium chloride and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium after repeated calcium chloride dosing and during long-term co-therapy. Adjust the calcium dose according to results.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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