Drug interactions
Calcium citrate + Digoxin
Severity: Moderate
Calcium citrate and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral calcium supplements may cause hypercalcemia in susceptible patients, increasing sensitivity to digoxin and arrhythmia risk. At usual doses with normal calcium the risk is low.
What this interaction means in plain words
Calcium citrate and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated serum calcium augments digoxin's inotropic and arrhythmogenic effects.
What to do
Monitor serum calcium periodically and avoid high-dose supplementation; separate dosing from digoxin by a couple of hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium citrate and Digoxin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Calcium citrate with Digoxin?
MediHelp rates the interaction as moderate. Calcium citrate and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral calcium supplements may cause hypercalcemia in susceptible patients, increasing sensitivity to digoxin and arrhythmia risk. At usual doses with normal calcium the risk is low.
How serious is the interaction between Calcium citrate and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically and avoid high-dose supplementation; separate dosing from digoxin by a couple of hours.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
