Drug interactions
Calcium citrate + Dolutegravir
Severity: Moderate
Calcium citrate and Dolutegravir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium citrate can reduce dolutegravir absorption through chelation, which may lower plasma levels and risk virologic failure. Taking both with a meal largely overcomes the effect.
What this interaction means in plain words
Calcium citrate and Dolutegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Calcium cations chelate dolutegravir in the gut, reducing absorption.
What to do
Give dolutegravir 2 hours before or 6 hours after calcium citrate, or co-administer with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Frequently asked questions
Can I take Calcium citrate with Dolutegravir?
MediHelp rates the interaction as moderate. Calcium citrate and Dolutegravir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium citrate can reduce dolutegravir absorption through chelation, which may lower plasma levels and risk virologic failure. Taking both with a meal largely overcomes the effect.
How serious is the interaction between Calcium citrate and Dolutegravir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give dolutegravir 2 hours before or 6 hours after calcium citrate, or co-administer with food.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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