Drug interactions
Dofetilide + Dolutegravir
Severity: Contraindicated
Dofetilide and Dolutegravir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolutegravir increases dofetilide plasma concentrations, which can prolong the QT interval and cause torsades de pointes. Dofetilide has a narrow therapeutic index, so even modest increases are dangerous.
What this interaction means in plain words
Dofetilide and Dolutegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dofetilide belongs to Cardiovascular; Dolutegravir belongs to Anti Virals.
Why it happens
Dolutegravir inhibits renal OCT2 and MATE1, reducing the tubular secretion of dofetilide.
What to do
Do not coadminister; select an alternative antiarrhythmic or a different antiretroviral.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dofetilide and Dolutegravir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dolutegravir
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Dolutegravir?
MediHelp rates the interaction as contraindicated. Dofetilide and Dolutegravir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dolutegravir increases dofetilide plasma concentrations, which can prolong the QT interval and cause torsades de pointes. Dofetilide has a narrow therapeutic index, so even modest increases are dangerous.
How serious is the interaction between Dofetilide and Dolutegravir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; select an alternative antiarrhythmic or a different antiretroviral.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Aluminum hydroxide, Atidarsagene autotemcel, Betibeglogene autotemcel. The full list is on the Dolutegravir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
