Drug interactions
Calcium citrate + Metolazone
Severity: Moderate
Calcium citrate and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics such as metolazone reduce renal calcium excretion, so calcium citrate supplements can lead to raised serum calcium. Risk rises with high supplement doses, vitamin D use or impaired kidney function.
What this interaction means in plain words
Calcium citrate and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Metolazone enhances distal tubular calcium reabsorption, decreasing urinary calcium loss.
What to do
Monitor serum calcium at baseline and periodically during combined therapy. Lower the calcium dose if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Calcium citrate with Metolazone?
MediHelp rates the interaction as moderate. Calcium citrate and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-type diuretics such as metolazone reduce renal calcium excretion, so calcium citrate supplements can lead to raised serum calcium. Risk rises with high supplement doses, vitamin D use or impaired kidney function.
How serious is the interaction between Calcium citrate and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium at baseline and periodically during combined therapy. Lower the calcium dose if hypercalcemia occurs.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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