Drug interactions
Calcium citrate + Vitamin d
Severity: Moderate
Calcium citrate and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D increases intestinal calcium absorption, and with calcium citrate can lead to hypercalcemia or hypercalciuria, particularly with high doses or renal impairment. Calcium citrate also enhances aluminium absorption in renal failure.
What this interaction means in plain words
Calcium citrate and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Vitamin D enhances gastrointestinal calcium absorption, increasing total calcium load.
What to do
Monitor serum calcium and renal function, and lower the vitamin D or calcium dose if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin d
Frequently asked questions
Can I take Calcium citrate with Vitamin d?
MediHelp rates the interaction as moderate. Calcium citrate and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, and with calcium citrate can lead to hypercalcemia or hypercalciuria, particularly with high doses or renal impairment. Calcium citrate also enhances aluminium absorption in renal failure.
How serious is the interaction between Calcium citrate and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and renal function, and lower the vitamin D or calcium dose if hypercalcemia occurs.
What other medicines interact with Vitamin d?
MediHelp also lists interactions of Vitamin d with, for example, Aluminum hydroxide, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Vitamin d page.
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