Drug interactions
Calcium gluconate + Chlorthalidone
Severity: Moderate
Calcium gluconate and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics retain calcium, so calcium gluconate may raise serum calcium further than expected. Clinically relevant hypercalcemia is more likely with frequent dosing or kidney disease.
What this interaction means in plain words
Calcium gluconate and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium gluconate belongs to Gastrointestinal Tract; Chlorthalidone belongs to Cardiovascular.
Why it happens
Chlorthalidone increases distal tubular calcium reabsorption, reducing renal calcium clearance.
What to do
Monitor serum calcium during repeated calcium gluconate administration with chlorthalidone. Reduce the calcium dose if hypercalcemia appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium gluconate and Chlorthalidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorthalidone
Other interactions of Calcium gluconate
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium gluconate + Digoxin Major
- Alendronate + Calcium gluconate Moderate
- Amlodipine-atorvastatin + Calcium gluconate Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Calcium gluconate Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcium gluconate Moderate
Frequently asked questions
Can I take Calcium gluconate with Chlorthalidone?
MediHelp rates the interaction as moderate. Calcium gluconate and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-like diuretics retain calcium, so calcium gluconate may raise serum calcium further than expected. Clinically relevant hypercalcemia is more likely with frequent dosing or kidney disease.
How serious is the interaction between Calcium gluconate and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium during repeated calcium gluconate administration with chlorthalidone. Reduce the calcium dose if hypercalcemia appears.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
