Drug interactions
Oxycodone + Tranylcypromine
Severity: Contraindicated
Oxycodone and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine with oxycodone can cause serotonin syndrome or severe opioid toxicity, including hypotension, hyperthermia and respiratory depression. Use during or within 14 days of MAOI therapy is not recommended by labeling.
What this interaction means in plain words
Oxycodone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Oxycodone belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Why it happens
Nonselective MAO inhibition combined with opioid serotonergic and CNS depressant effects; mechanism not fully defined.
What to do
Do not co-administer and allow 14 days after stopping the MAOI. Use a non-opioid alternative analgesic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Oxycodone with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Oxycodone and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine with oxycodone can cause serotonin syndrome or severe opioid toxicity, including hypotension, hyperthermia and respiratory depression. Use during or within 14 days of MAOI therapy is not recommended by labeling.
How serious is the interaction between Oxycodone and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer and allow 14 days after stopping the MAOI. Use a non-opioid alternative analgesic.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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