Drug interactions
Calcium / magnesium / potassium / sodium oxybates + Trazodone
Severity: Major
Calcium / magnesium / potassium / sodium oxybates and Trazodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybates cause profound CNS and respiratory depression, and trazodone is a sedating antidepressant that adds to this effect. Combined use can lead to marked sedation, respiratory depression, coma and death.
What this interaction means in plain words
Calcium / magnesium / potassium / sodium oxybates and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression through pharmacodynamic synergism.
What to do
Avoid the combination where possible; if both are essential, use the lowest effective doses for the shortest duration. Monitor closely for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Calcium / magnesium / potassium / sodium oxybates with Trazodone?
MediHelp rates the interaction as major. Calcium / magnesium / potassium / sodium oxybates and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxybates cause profound CNS and respiratory depression, and trazodone is a sedating antidepressant that adds to this effect. Combined use can lead to marked sedation, respiratory depression, coma and death.
How serious is the interaction between Calcium / magnesium / potassium / sodium oxybates and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if both are essential, use the lowest effective doses for the shortest duration. Monitor closely for sedation and respiratory depression.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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