Drug interactions
Canagliflozin + Captopril
Severity: Moderate
Canagliflozin and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin does not typically raise potassium, though in some patients it may. Combined with an ACE inhibitor, the principal concerns are volume depletion, hypotension and acute kidney injury.
What this interaction means in plain words
Canagliflozin and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Captopril belongs to Cardiovascular.
Why it happens
Additive effects on renal hemodynamics and volume status: SGLT2-induced diuresis and ACE inhibitor efferent arteriolar dilation.
What to do
Check volume status, blood pressure, renal function and potassium after starting canagliflozin. Consider reducing diuretic doses if the patient is volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Captopril?
MediHelp rates the interaction as moderate. Canagliflozin and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin does not typically raise potassium, though in some patients it may. Combined with an ACE inhibitor, the principal concerns are volume depletion, hypotension and acute kidney injury.
How serious is the interaction between Canagliflozin and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check volume status, blood pressure, renal function and potassium after starting canagliflozin. Consider reducing diuretic doses if the patient is volume depleted.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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