Drug interactions
Canagliflozin + Cyclosporine
Severity: Moderate
Canagliflozin and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can cause hyperkalemia and nephrotoxicity, and canagliflozin may modestly raise potassium and alter renal hemodynamics. Together they may increase the risk of elevated potassium and renal function changes.
What this interaction means in plain words
Canagliflozin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on potassium handling: cyclosporine impairs renal potassium excretion while canagliflozin may modestly raise potassium.
What to do
Monitor serum potassium and renal function regularly during combined therapy. Adjust therapy if hyperkalemia or declining eGFR develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Cyclosporine?
MediHelp rates the interaction as moderate. Canagliflozin and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can cause hyperkalemia and nephrotoxicity, and canagliflozin may modestly raise potassium and alter renal hemodynamics. Together they may increase the risk of elevated potassium and renal function changes.
How serious is the interaction between Canagliflozin and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function regularly during combined therapy. Adjust therapy if hyperkalemia or declining eGFR develops.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
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