Drug interactions
Canagliflozin + Enalapril
Severity: Moderate
Canagliflozin and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors reduce aldosterone and raise potassium. Canagliflozin has been associated with small increases in potassium in some patients, particularly with renal impairment, so hyperkalemia may be more likely. Canagliflozin also adds volume depletion and hypotension risk with enalapril.
What this interaction means in plain words
Canagliflozin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Enalapril belongs to Cardiovascular.
Why it happens
Additive potassium-raising effect of ACE inhibition and canagliflozin, plus additive volume depletion and hypotension.
What to do
Monitor serum potassium, renal function and blood pressure after starting canagliflozin, especially in patients with CKD. Correct volume depletion and reassess doses if hyperkalemia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Enalapril?
MediHelp rates the interaction as moderate. Canagliflozin and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors reduce aldosterone and raise potassium. Canagliflozin has been associated with small increases in potassium in some patients, particularly with renal impairment, so hyperkalemia may be more likely. Canagliflozin also adds volume depletion and hypotension risk with enalapril.
How serious is the interaction between Canagliflozin and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and blood pressure after starting canagliflozin, especially in patients with CKD. Correct volume depletion and reassess doses if hyperkalemia or hypotension develops.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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