Drug interactions
Canagliflozin + Insulin isophane human / insulin regular human
Severity: Moderate
Canagliflozin and Insulin isophane human / insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding canagliflozin to insulin lowers glucose further and increases the risk of hypoglycemia. Insulin dose requirements often fall when an SGLT2 inhibitor is started.
What this interaction means in plain words
Canagliflozin and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering through insulin action and insulin-independent urinary glucose excretion.
What to do
Monitor blood glucose and consider reducing the insulin dose when starting canagliflozin. Counsel patients on hypoglycemia and ketoacidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Insulin isophane human / insulin regular human?
MediHelp rates the interaction as moderate. Canagliflozin and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding canagliflozin to insulin lowers glucose further and increases the risk of hypoglycemia. Insulin dose requirements often fall when an SGLT2 inhibitor is started.
How serious is the interaction between Canagliflozin and Insulin isophane human / insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and consider reducing the insulin dose when starting canagliflozin. Counsel patients on hypoglycemia and ketoacidosis symptoms.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
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