Drug interactions
Canagliflozin + Insulin neutral human-insulin isophane protamine human
Severity: Moderate
Canagliflozin and Insulin neutral human-insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding canagliflozin to insulin lowers blood glucose further and can cause hypoglycemia unless the insulin dose is reduced. SGLT2 inhibitors with insulin also carry a risk of euglycemic diabetic ketoacidosis if insulin is cut too far.
What this interaction means in plain words
Canagliflozin and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Insulin neutral human-insulin isophane protamine human belongs to Endocrine.
Why it happens
Additive glucose-lowering effect through insulin action plus SGLT2-mediated urinary glucose excretion.
What to do
Monitor blood glucose when starting canagliflozin and consider a modest insulin dose reduction. Avoid large insulin reductions and monitor for ketosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Insulin neutral human-insulin isophane protamine human?
MediHelp rates the interaction as moderate. Canagliflozin and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding canagliflozin to insulin lowers blood glucose further and can cause hypoglycemia unless the insulin dose is reduced. SGLT2 inhibitors with insulin also carry a risk of euglycemic diabetic ketoacidosis if insulin is cut too far.
How serious is the interaction between Canagliflozin and Insulin neutral human-insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting canagliflozin and consider a modest insulin dose reduction. Avoid large insulin reductions and monitor for ketosis symptoms.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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