Drug interactions
Canagliflozin + Olmesartan
Severity: Moderate
Canagliflozin and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin has been associated with small increases in serum potassium, especially in patients with renal impairment or on RAAS inhibitors. It can also cause volume depletion and hypotension, adding to the effects of olmesartan and risking acute kidney injury.
What this interaction means in plain words
Canagliflozin and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Olmesartan belongs to Cardiovascular.
Why it happens
Canagliflozin-induced natriuresis and volume depletion plus ARB-related reduced aldosterone effect may affect renal function and potassium balance.
What to do
Assess volume status and monitor blood pressure, renal function and potassium after starting canagliflozin, and reduce diuretic or olmesartan doses if volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Olmesartan?
MediHelp rates the interaction as moderate. Canagliflozin and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin has been associated with small increases in serum potassium, especially in patients with renal impairment or on RAAS inhibitors. It can also cause volume depletion and hypotension, adding to the effects of olmesartan and risking acute kidney injury.
How serious is the interaction between Canagliflozin and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and monitor blood pressure, renal function and potassium after starting canagliflozin, and reduce diuretic or olmesartan doses if volume depletion occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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