Drug interactions
Canagliflozin + Perindopril
Severity: Moderate
Canagliflozin and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin has been associated with small rises in serum potassium, and ACE inhibitors raise potassium by reducing aldosterone. Hyperkalemia is more likely with renal impairment. Both drugs can also cause volume depletion and a fall in renal function.
What this interaction means in plain words
Canagliflozin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
Perindopril reduces aldosterone-mediated potassium excretion, while canagliflozin can raise potassium and cause volume depletion, with additive effects.
What to do
Monitor serum potassium, renal function and volume status after starting canagliflozin in patients on perindopril. Adjust therapy if hyperkalemia or significant renal decline develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Perindopril?
MediHelp rates the interaction as moderate. Canagliflozin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin has been associated with small rises in serum potassium, and ACE inhibitors raise potassium by reducing aldosterone. Hyperkalemia is more likely with renal impairment. Both drugs can also cause volume depletion and a fall in renal function.
How serious is the interaction between Canagliflozin and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and volume status after starting canagliflozin in patients on perindopril. Adjust therapy if hyperkalemia or significant renal decline develops.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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