Drug interactions
Canagliflozin + Rifampin
Severity: Moderate
Canagliflozin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces UGT enzymes that metabolize canagliflozin, lowering its exposure and glucose-lowering effect. Glycemic control may worsen.
What this interaction means in plain words
Canagliflozin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of UGT-mediated glucuronidation increases canagliflozin clearance.
What to do
Monitor glycemic control; per labeling, consider increasing canagliflozin from 100 mg to 300 mg daily if eGFR permits, or use another antihyperglycemic agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Rifampin?
MediHelp rates the interaction as moderate. Canagliflozin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces UGT enzymes that metabolize canagliflozin, lowering its exposure and glucose-lowering effect. Glycemic control may worsen.
How serious is the interaction between Canagliflozin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control; per labeling, consider increasing canagliflozin from 100 mg to 300 mg daily if eGFR permits, or use another antihyperglycemic agent.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
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