Drug interactions
Canagliflozin + Sacubitril / valsartan
Severity: Moderate
Canagliflozin and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan can raise serum potassium, and canagliflozin may modestly add to this in susceptible patients. Both may also cause volume depletion, hypotension and eGFR changes.
What this interaction means in plain words
Canagliflozin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on potassium and renal hemodynamics through angiotensin receptor blockade and SGLT2 inhibition.
What to do
Monitor serum potassium, renal function and blood pressure after initiation. Adjust doses if hyperkalemia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Canagliflozin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan can raise serum potassium, and canagliflozin may modestly add to this in susceptible patients. Both may also cause volume depletion, hypotension and eGFR changes.
How serious is the interaction between Canagliflozin and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and blood pressure after initiation. Adjust doses if hyperkalemia or hypotension occurs.
What other medicines interact with Canagliflozin?
MediHelp also lists interactions of Canagliflozin with, for example, Aliskiren, Amiloride, Amlodipine-benazepril. The full list is on the Canagliflozin page.
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